Top 4 Topical Neuropathy Creams For Nerve Pain Relief of 2021

Written by Mary | Last Updated on 
November 13th, 2020 at 07:00 pm

Peripheral neuropathy can cause pain in the hands, arms, legs, and feet. If you have diabetes, your chances of developing nerve pain can increase.

Nerve pain can make your life difficult, adding obstacles to performing everyday activities. 

If you have been experiencing nerve pain for quite some time and need a solution to reduce it, consider investing in a topical neuropathy cream for nerve pain relief.

When it comes to topical neuropathy creams for nerve pain relief, you have tons of options to choose from. 

You do not want to invest your money in buying a topical neuropathy cream that does not make any difference to your nerve pain, which is why knowing about the most popular creams for pain relief will help you decide.

In this review, I have reviewed a few of the most popular topical neuropathy creams for nerve pain relief. By reading my detailed review of each pain relief cream for peripheral neuropathy, you can make a good purchasing decision.

1. Nervex Neuropathy Pain Relief by Vita Sciences

Nervex Neuropathy Pain Relief by Vita Sciences is an advanced topical neuropathy cream. You can use it to reduce pain due to peripheral neuropathy and fibromyalgia. The cream contains a range of vitamins and nutrients.

A bottle of Nervex Neuropathy Pain Relief.

Before putting the vitamins and nutrients into the nerve pain relief cream, the company measures the doses using an airless dispenser.

Before adding any ingredients into the formula, the company performs extensive research on every ingredient, backing it up with studies. When you use the cream, you won’t have to worry about odor as it is odor-free.

The two main ingredients found in the topical neuropathy cream is vitamin B12 and vitamin E, which the company has put in high doses for the maximum effect on alleviating nerve pain.

Other ingredients found in the cream include vitamin B1, vitamin B5, vitamin B6, MSM, Capsaicin, Andrographis, and Cetyl Myristoleate. All these ingredients work together to reduce the symptoms of peripheral neuropathy and support synapse repair.

Also found in the cream are moisturizers and antioxidants that make it into a power absorbent. When you apply this topical neuropathy cream on your skin, it will absorb it quickly.

You will not experience any allergic reactions to the neuropathy cream, as it is made up of all-natural ingredients. It will be gentle on your skin. If applied in measured amounts, you can apply it 30 times on the affected area.


The cream is clinically tested and hypoallergenic and is made from natural ingredients with vitamin B12 and vitamin E being the two main ones. It has received several positive reviews with people saying that they have experienced a decrease in painful numbness, muscle spasms, routine pain, and burning or tingling sensations in their hands, arms, legs, and feet.

The cream costs $18.95 and is affordable. If you want to find nerve pain relief, I would suggest that you give Nervex Neuropathy Pain Relief a try.

2. Insta-Relief DM Pain Relieving Cream by Insta-Relief DM

Insta-Relief DM Pain Relieving Cream by Insta-Relief DM can provide people suffering from diabetic neuropathy with instantaneous relief. You need to rub the cream on the area of pain and within seconds, you will find relief.

A jar of Insta-Relief DM Pain Relieving Cream

The topical neuropathy cream reduces tingling, burning, and numbness in the hands, knees, legs, and muscles.

The company states that their cream restores people’s lost comfort and allows them to become active and healthy again. The cream receives its quick healing powers from plant-derived ingredients. 

These ingredients promote nerve health and facilitate the healing process by reducing the painful symptoms of peripheral neuropathy. The cream is also safe and gentle on the skin. When applied, it will not irritate your skin.

You can use it to treat your sores safely each day. If you are in extreme pain, you can use it four times each day. The cream has a calm and cooling effect. The Bureau of Food and Drugs Administration (FDA) has approved the cream and the company states that even doctors recommend the cream to patients with nerve pain. Apart from relieving the pain related to peripheral neuropathy, people with arthritis can also use it.


The topical neuropathy is slightly on the expensive side, costing $24.99. It also does not have a lot of reviews. Some positive aspects of the topical cream include that it is FDA-approved and uses plant-derived ingredients. The company also complains that doctors often provide this topical neuropathy cream to their patients.

It also provides instant pain relief combined with intensive healing and repair of the affected nerves to minimize the tingling and burning sensation and numbness in your hands, legs, feet, knees, and muscles. Most of the reviews of the cream are positive versus negative ones.

If you experience severe pain and need instant pain relief, you can buy it, but since even the positive reviews are less and it is a little costly, you may want to look at buying other topical neuropathy creams for nerve pain relief.

3. Neuropathy by Nuturna

Neuropathy provides people with nerve pain several benefits. Formulated by Nuturna, a company known for using carefully-researched, natural and trusted ingredients, the cream provides fast-acting relief.

Nuturna neuropathy pain relief cream

The cream penetrates deep into the skin to reduce pain at the source, offers intense cooling and soothing, offers immediate pain relief, promotes and healing and recovery, promotes normal and healthy nerve function, increases blood circulation and skin healing, and decreases swelling and inflammation.

The topical cream contains key ingredients, such as arnica, vitamin E, vitamin B6, Menthol, MSN, aloe vera, and tea tree oil. The cream functions by stimulating the sensory pathways located underneath the skin and restoring blood circulation to the legs, arms, feet, and hands.

When you use the cream, your body’s TRPA1 Channels will become active. TRPA1 Channels are essential to your body, as they are responsible for the cold and heat sensations you experience on your skin. The company, which has been around since 2009, also claims that their cream is 100% doctor- approved.

For the best results, the company also encourages buyers to use the topical neuropathy cream for nerve pain relief with the Neuropathy Support Formula, containing vitamins and minerals and 18 herbs for nerve relief and regeneration.


Even though Neuropathy by Nuturna provides you with an abundance of benefits, the company encourages its customers to buy supplements with it to get the best results. This means that topical neuropathy cream alone may not be as effective.

With the company being in the business of selling nerve pain creams and supplements for several years, the chances of the cream working to relieve nerve pain are high. The cream costs $23.72, which may be too expensive for someone to buy.

In my opinion, buying the topical neuropathy cream may not be a bad idea due to the number of benefits it provides. The company also states that doctors often recommend this topical pain-relieving cream to patients with nerve pain.

4. Nature Remedies by 100% Natural Products

Nature Remedies by 100% Natural Products is an antiseptic cream used to treat a variety of different ailments.

A jar of Nature Remedies natural antiseptic cream

You can use the topical cream to alleviate neuropathy pain, severe skin irritation, bed sores, psoriasis, eczema, poison ivy, dry and cracked skin, sore muscles and joint pain, insect bites, infected skin, abrasions, and ulcers.

The main ingredient in the topical pain-relieving cream is natural vitamin E and rosemary extract.

Other natural ingredients in the topical neuropathy cream include beeswax, cocoa butter, shea butter, coconut oil, peppermint, avocado butter, aloe butter, tea tree, olive oil, and more.

The company credits a professional former Burt’s Bees Associate for developing the formula. The professional who developed the formula has expertise in essential oils and plant extracts.

The company states that their cream for nerve pain is not FDA-approved and people should not use it with the aim of treating, curing, or preventing a disease or medical condition.


Nature Remedies will not be a waste of money, as it can help soothe and heal more than just peripheral neuropathy. Since the topical neuropathy cream costs $15.11, you will not regret purchasing it due to the low cost.

Your money will also not go down the drain if it does not work for you. It might work for another person in your family due to the number of skin conditions it can heal.

The reviews of the topical neuropathy cream are mostly positive with most saying that it works for nerve pain. I would suggest that you buy the topical neuropathy cream for nerve pain to see if it minimizes the nerve pain related to peripheral neuropathy.

From this list of topical neuropathy creams, choose the one that you think will work best for treating your nerve pain due to peripheral neuropathy.


While using a topical cream for diabetic or peripheral neuropathy can help provide short-term pain relief with little to no side effects, it should not be your only treatment method. 

Other treatment options include taking supplements like Nerve Renew Neuropathy Support Formula, which has several highly bioavailable B-vitamins, Alpha Lipoic Acid, and other herbs. You can read our full review of the product here.